Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0DS7W
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| Former ID |
DNC008516
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| Drug Name |
1-(3-chloropyridin-2-yl)-4-tosylpiperazine
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| Synonyms |
arylsulfonylpiperazine, 25; CHEMBL403685; SCHEMBL3217790; BDBM32553
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H18ClN3O2S
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| Canonical SMILES |
CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
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| InChI |
1S/C16H18ClN3O2S/c1-13-4-6-14(7-5-13)23(21,22)20-11-9-19(10-12-20)16-15(17)3-2-8-18-16/h2-8H,9-12H2,1H3
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| InChIKey |
DAJKQJMXMSAPCV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolism of xenobiotics by cytochrome P450 | ||||
| Metabolic pathways | ||||
| Chemical carcinogenesis | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Pathwhiz Pathway | Steroidogenesis | |||
| Reactome | Glucocorticoid biosynthesis | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. | |||
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