Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D6VE
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Former ID |
DAP000286
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Drug Name |
Pegvisomant
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Synonyms |
Somavent; Pegvisomant (genetical recombination); Somavent (TN); Somavert (TN); Pegvisomant (USAN/INN); Pegvisomant (genetical recombination) (JAN)
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Indication | Acromegaly [ICD-11: 5A60.0; ICD-10: E22.0; ICD-9: 253] | Approved | [1], [2] | |
Therapeutic Class |
Anabolic Agents
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Company |
Abbott Laboratories
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PubChem Substance ID | ||||
ADReCS Drug ID | BADD_D01699 | |||
SuperDrug ATC ID |
H01AX01
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Target and Pathway | Top | |||
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Target(s) | Growth hormone receptor (GHR) | Target Info | Antagonist | [3], [4], [5], [6], [7] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Neuroactive ligand-receptor interaction | ||||
PI3K-Akt signaling pathway | ||||
Jak-STAT signaling pathway | ||||
Pathway Interaction Database | Notch-mediated HES/HEY network | |||
Reactome | Prolactin receptor signaling | |||
Growth hormone receptor signaling | ||||
WikiPathways | Endochondral Ossification | |||
Prolactin receptor signaling | ||||
Growth hormone receptor signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7485). | |||
REF 2 | Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90. | |||
REF 3 | Growth hormone receptor antagonist treatment reduces exercise performance in young males. J Clin Endocrinol Metab. 2009 Sep;94(9):3265-72. | |||
REF 4 | Pituitary tumors. Curr Treat Options Neurol. 2009 Jul;11(4):287-96. | |||
REF 5 | Current therapy and drug pipeline for the treatment of patients with acromegaly. Adv Ther. 2009 Apr;26(4):383-403. | |||
REF 6 | Growth hormone receptor antagonists. Minerva Endocrinol. 2002 Dec;27(4):287-98. | |||
REF 7 | Growth hormone receptor antagonist improves insulin resistance in acromegaly. Growth Horm IGF Res. 2002 Dec;12(6):418-24. |
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