Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D4UT
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Former ID |
DIB016276
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Drug Name |
GSK2849330
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Drug Type |
Antibody
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
Company |
Glaxosmithkline
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Target and Pathway | Top | |||
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Target(s) | Erbb3 tyrosine kinase receptor (Erbb-3) | Target Info | . | [2] |
KEGG Pathway | ErbB signaling pathway | |||
Calcium signaling pathway | ||||
Endocytosis | ||||
Proteoglycans in cancer | ||||
MicroRNAs in cancer | ||||
NetPath Pathway | TNFalpha Signaling Pathway | |||
Panther Pathway | Cadherin signaling pathway | |||
EGF receptor signaling pathway | ||||
Pathway Interaction Database | ErbB2/ErbB3 signaling events | |||
ErbB receptor signaling network | ||||
a6b1 and a6b4 Integrin signaling | ||||
WikiPathways | ErbB Signaling Pathway | |||
Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
Signaling Pathways in Glioblastoma | ||||
miR-targeted genes in muscle cell - TarBase | ||||
Heart Development |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01966445) Dose Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of GSK2849330 in Subjects With Advanced Her3-Positive Solid Tumors. U.S. National Institutes of Health. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). |
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