Drug Information
Drug General Information | Top | |||
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Drug ID |
D0CQ1J
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Former ID |
DNC000051
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Drug Name |
2'-aminoimidazolylmethyluracils
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C8H10ClN5O2
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Canonical SMILES |
C1=CN(C(N1)N)CC2=C(C(=O)NC(=O)N2)Cl
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InChI |
1S/C8H10ClN5O2/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10/h1-2,7,11H,3,10H2,(H2,12,13,15,16)
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InChIKey |
VDNGDZIPDSUEKT-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
KEGG Pathway | Pyrimidine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Bladder cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
WikiPathways | Bladder Cancer | |||
Metabolism of nucleotides | ||||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16;46(2):207-9. |
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