Drug Information
Drug General Information | Top | |||
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Drug ID |
D0C2BP
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Drug Name |
AG-270
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Synonyms |
REOUTEBTFSILJY-UHFFFAOYSA-N; AG 270; 3(2H)-Pyridazinone, 6-(m-methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-, hydrochloride; 6-(m-Methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-3(2H)-pyridazinone hydrochloride; Morpholinoethyl-2 methyl-4 (m-methoxyphenyl)-6 pyridazone-3 chlorhydrate [French]; 13299-99-5; AC1L496O; DTXSID20157888; Morpholinoethyl-2 methyl-4 (m-methoxyphenyl)-6 pyridazone-3 chlorhydrate; LS-130006; 6-(3-methoxyphenyl)-4-methyl-2-(2-morpholin-4-ylethyl)pyridazin-3-one hydrochloride
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Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 1 | [1] | |
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | ||
Company |
Agios Pharmaceuticals Cambridge, MA
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Structure |
Download2D MOL |
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Formula |
C18H24ClN3O3
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Canonical SMILES |
CC1=CC(=NN(C1=O)CCN2CCOCC2)C3=CC(=CC=C3)OC.Cl
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InChI |
1S/C18H23N3O3.ClH/c1-14-12-17(15-4-3-5-16(13-15)23-2)19-21(18(14)22)7-6-20-8-10-24-11-9-20;/h3-5,12-13H,6-11H2,1-2H3;1H
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InChIKey |
REOUTEBTFSILJY-UHFFFAOYSA-N
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CAS Number |
CAS 13299-99-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | S-adenosylmethionine synthase type-2 (MAT2A) | Target Info | Inhibitor | [1] |
KEGG Pathway | Cysteine and methionine metabolism | |||
Metabolic pathways | ||||
Biosynthesis of amino acids |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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