Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B8JQ
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| Former ID |
DIB006878
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| Drug Name |
KRP-101
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| Synonyms |
PPAR alpha agonist (hyperlipidemia), Kyorin
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| Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Discontinued in Phase 2 | [1] | |
| Company |
Kyorin Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C26H26FNO5
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| Canonical SMILES |
CCC(CC1=CC(=C(C=C1)OC)C(=O)NCC2=CC=C(C=C2)OC3=CC=C(C=C3)F)C(=O)O
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| InChI |
1S/C26H26FNO5/c1-3-19(26(30)31)14-18-6-13-24(32-2)23(15-18)25(29)28-16-17-4-9-21(10-5-17)33-22-11-7-20(27)8-12-22/h4-13,15,19H,3,14,16H2,1-2H3,(H,28,29)(H,30,31)/t19-/m0/s1
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| InChIKey |
VRHOBXXCNBZJRX-IBGZPJMESA-N
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| CAS Number |
CAS 311770-26-0
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018628) | |||
| REF 2 | Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. Biochem Pharmacol. 2009 Sep 1;78(5):523-30. | |||
| REF 3 | A novel PPARalpha agonist ameliorates insulin resistance in dogs fed a high-fat diet. Am J Physiol Endocrinol Metab. 2008 May;294(5):E833-40. | |||
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