Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B3QI
|
|||
| Drug Name |
Dihydropyrido phthalazinone derivative 1
|
|||
| Synonyms |
PMID27841036-Compound-21
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H16F2N6O
|
|||
| Canonical SMILES |
CN1C(=NC=N1)C2C(CNC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
|
|||
| InChI |
1S/C20H16F2N6O/c1-28-19(24-9-25-28)17-14(10-2-4-11(21)5-3-10)8-23-15-7-12(22)6-13-16(15)18(17)26-27-20(13)29/h2-7,9,14,17,23H,8H2,1H3,(H,27,29)
|
|||
| InChIKey |
BGMPCZSIPWMURU-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.