Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0AZ4T
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| Former ID |
DNC000559
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| Drug Name |
Dihydroorotate
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| Synonyms |
Dihydroorotic acid; hydroorotic acid; 4,5-dihydroorotic acid; DL-Dihydroorotic acid; 155-54-4; 5,6-dihydroorotate; dihydroorotate; 2,6-dioxohexahydropyrimidine-4-carboxylic acid; 2,6-dioxo-1,3-diazinane-4-carboxylic acid; hexahydro-2,6-dioxo-4-Pyrimidinecarboxylic acid; 6202/10/4; CHEBI:30865; L-Hydroorotic acid; 4,5-dihydroorotate; 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; Orotic acid, 4,5-dihydro-; L-hydroorotate; R,S-Hydroorotate; 2,6-dioxohexahydro-4-pyrimidincarbons; DL-dihydroortotic acid; AC1Q6GGT; Dihydroorotic Acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H5N2O4-
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| Canonical SMILES |
C1C(NC(=O)NC1=O)C(=O)[O-]
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| InChI |
1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1
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| InChIKey |
UFIVEPVSAGBUSI-UHFFFAOYSA-M
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7723002, 8147950, 8150724, 10529020, 15243204, 24439010, 24894067, 51074268, 53788891, 57320371, 80159028, 85085441, 87245400, 91685710, 92298307, 103111954, 103274950, 104295439, 117593758, 117609103, 118239446, 125354050, 125539468, 125539521, 126523350, 129360419, 132510716, 135077112, 136995572, 137005525, 143263990, 143512009, 162089967, 162194773, 162797045, 163788444, 164787438, 169956461, 184572162, 184597045, 202820905, 204426224, 204426225, 226493331, 241124522, 242066009, 249841590, 252348685, 252351221
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| ChEBI ID |
CHEBI:30867
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotase (Malaria dho) | Target Info | Inhibitor | [1] |
| Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
| REF 2 | Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16. | |||
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