Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AG8C
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| Drug Name |
GC376
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| Synonyms |
CS-6923; HY-100721; CHEMBL2315036
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| Drug Type |
Small molecular drug
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| Indication | Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Preclinical | [1] | |
| Severe acute respiratory syndrome (SARS) [ICD-11: 1D65] | Preclinical | [1] | ||
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL |
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| Formula |
C21H30N3NaO8S
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| Canonical SMILES |
CC(C)CC(C(=O)NC(CC1CCNC1=O)C(O)S(=O)(=O)[O-])NC(=O)OCC2=CC=CC=C2.[Na+]
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| InChI |
1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/p-1/t15?,16-,17-,20?;/m0./s1
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| InChIKey |
BSPJDKCMFIPBAW-JPBGFCRCSA-M
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| CAS Number |
CAS 1416992-39-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | COVID-19 3C-like protease (3CLpro) | Target Info | Inhibitor | [2] |
| MERS-CoV 3C-like proteinase (3CLpro) | Target Info | Inhibitor | [1] | |
| SARS-CoV 3C-like protease (3CLpro) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016 Mar 30;12(3):e1005531. | |||
| REF 2 | Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 2020. April 20. doi: https://doi.org/10.1101/2020.04.20.051581 | |||
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