Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A1KU
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Former ID |
DNC010247
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Drug Name |
PF-3274167
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Synonyms |
PF-3274167; Cligosiban; 900510-03-4; UNII-D361S17AIF; D361S17AIF; CHEMBL594828; 5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine; Cligosiban [INN]; 5-{3-[3-(2-chloro-4-fluorophenoxy)azetidin-1-yl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl}-2-methoxypyridine; SCHEMBL4126605; EX-A297; MolPort-044-567-557; BCP08878; ZINC38239529; BDBM50305506; AKOS030526977; CS-5337; HY-15023; PF3274167; B5924; PF 3274167; J-690387; Pyridine, 5-(3-(3-(2-chloro-4-fluorophenoxy)-1-azetidinyl)-5
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Drug Type |
Small molecular drug
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Indication | Female sexual arousal dysfunction [ICD-11: HA01.1; ICD-9: 302.7] | Discontinued in Phase 1 | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H19ClFN5O3
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Canonical SMILES |
COCC1=NN=C(N1C2=CN=C(C=C2)OC)N3CC(C3)OC4=C(C=C(C=C4)F)Cl
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InChI |
1S/C19H19ClFN5O3/c1-27-11-17-23-24-19(26(17)13-4-6-18(28-2)22-8-13)25-9-14(10-25)29-16-5-3-12(21)7-15(16)20/h3-8,14H,9-11H2,1-2H3
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InChIKey |
HNIFCPBQMKPRCX-UHFFFAOYSA-N
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CAS Number |
CAS 900510-03-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Oxytocin receptor (OTR) | Target Info | Inhibitor | [2] |
Vasopressin V1a receptor (V1AR) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
cAMP signaling pathway | ||||
Oxytocin signaling pathway | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
Panther Pathway | Oxytocin receptor mediated signaling pathway | |||
Reactome | Vasopressin-like receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Myometrial Relaxation and Contraction Pathways | ||||
Oxytocin signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025596) | |||
REF 2 | Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. |
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