Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09ZKB
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| Former ID |
DIB014078
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| Drug Name |
Ad35-GRIN/ENV
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| Synonyms |
Ad35 vector-delivered gag/rt/int/nef + Ad35 vector-delivered env combination vaccine (HIV infection), International AIDS Vaccine Initiative
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| Drug Type |
Vaccine
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 1 | [1] | |
| Company |
International AIDS Vaccine Initiative
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) | Target Info | . | [2] |
| Human immunodeficiency virus GAG protein (HIV gag) | Target Info | . | [2] | |
| Human immunodeficiency virus Negative factor (HIV nef) | Target Info | . | [2] | |
| Human immunodeficiency virus Rev protein (HIV rev) | Target Info | . | [2] | |
| Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | . | [2] | |
| Reactome | Uncoating of the HIV Virion | |||
| Budding and maturation of HIV virion | ||||
| Integration of provirus | ||||
| Early Phase of HIV Life Cycle | ||||
| Minus-strand DNA synthesis | ||||
| Plus-strand DNA synthesis | ||||
| 2-LTR circle formation | ||||
| Binding and entry of HIV virion | ||||
| Assembly Of The HIV Virion | ||||
| Integration of viral DNA into host genomic DNA | ||||
| Autointegration results in viral DNA circles | ||||
| APOBEC3G mediated resistance to HIV-1 infection | ||||
| Vpr-mediated nuclear import of PICs | ||||
| Membrane binding and targetting of GAG proteins | ||||
| WikiPathways | Host Interactions of HIV factors | |||
| HIV Life Cycle | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01496989) Safety and Immunogenicity Study of HIV-MAG Vaccine +/- IL-12 and Ad35-GRIN/ENV in HIV-uninfected Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. | |||
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