Drug Information
Drug General Information | Top | |||
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Drug ID |
D09TBA
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Former ID |
DNC007874
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Drug Name |
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione
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Synonyms |
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione; 18493-82-8; Oprea1_007440; SCHEMBL2672214; CHEMBL394673; BDBM20060; LWRITIARHSTBLU-UHFFFAOYSA-N; 5-Substituted-6-chlorouracil, 5g; 5-benzyl-6-chloro-1H-pyrimidine-2,4-dione; SR-01000516321; SR-01000516321-1
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H9ClN2O2
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Canonical SMILES |
C1=CC=C(C=C1)CC2=C(NC(=O)NC2=O)Cl
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InChI |
1S/C11H9ClN2O2/c12-9-8(10(15)14-11(16)13-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,13,14,15,16)
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InChIKey |
LWRITIARHSTBLU-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
KEGG Pathway | Pyrimidine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Bladder cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
WikiPathways | Bladder Cancer | |||
Metabolism of nucleotides | ||||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. |
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