Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09SYD
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| Drug Name |
Pyrazolo[1,5-a]pyrimidine derivative 26
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| Synonyms |
PMID28270010-Compound-Figure9-3
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| Drug Type |
Small molecular drug
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| Company |
ARRAY BIOPHARMA INC. HAAS, Julia ANDREWS, Steven, W. JIANG, Yutong ZHANG, Gan
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H27FN6O3
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| Canonical SMILES |
COC1=C(C=C(C=C1)F)C2CCCN2C3=NC4=C(C=NN4C=C3)NC(=O)N5CCCC(C5)O
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| InChI |
1S/C23H27FN6O3/c1-33-20-7-6-15(24)12-17(20)19-5-3-10-29(19)21-8-11-30-22(27-21)18(13-25-30)26-23(32)28-9-2-4-16(31)14-28/h6-8,11-13,16,19,31H,2-5,9-10,14H2,1H3,(H,26,32)/t16-,19+/m0/s1
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| InChIKey |
RGIQATAASXNYCK-QFBILLFUSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tropomyosin-related kinase A (TrkA) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tropomyosin-related kinase A (TrkA) | Target's Patent Info | [1] | |
| KEGG Pathway | MAPK signaling pathway | |||
| Endocytosis | ||||
| Apoptosis | ||||
| Neurotrophin signaling pathway | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Thyroid cancer | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling | |||
| Reactome | Frs2-mediated activation | |||
| ARMS-mediated activation | ||||
| NGF-independant TRKA activation | ||||
| PI3K/AKT activation | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| BDNF signaling pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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