Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09FKY
|
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| Former ID |
DIB004608
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| Drug Name |
GED-0301
|
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| Synonyms |
SMAD-7 inhibitor (oligonucleotide, Crohn's disease), Giuliani
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|
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| Indication | Crohn disease [ICD-11: DD70; ICD-10: K50, K50.9; ICD-9: 555] | Phase 3 | [1] | |
| Ulcerative colitis [ICD-11: DD71; ICD-9: 556] | Phase 2 | [1] | ||
| Company |
Giuliani SpA
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mothers against decapentaplegic homolog 7 (SMAD7) | Target Info | Inhibitor | [1] |
| Smad7 messenger RNA (Smad7 mRNA) | Target Info | Inhibitor | [2], [3] | |
| KEGG Pathway | Endocytosis | |||
| TGF-beta signaling pathway | ||||
| Hippo signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | TGF-beta signaling pathway | |||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class I | ||||
| IFN-gamma pathway | ||||
| BMP receptor signaling | ||||
| ALK1 signaling events | ||||
| TGF-beta receptor signaling | ||||
| Reactome | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | |||
| WikiPathways | TGF Beta Signaling Pathway | |||
| TGF beta Signaling Pathway | ||||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Signaling by BMP | ||||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Signaling by TGF-beta Receptor Complex | ||||
| Integrated Breast Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7. | |||
| REF 3 | Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther. 2012 Apr;20(4):870-6. | |||
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