Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09DHT
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| Former ID |
DIB020710
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| Drug Name |
phorbol 12-myristate 13-acetate
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| Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 2 | [1] | |
| Hodgkin lymphoma [ICD-11: 2B30; ICD-10: C81, C81.9] | Phase 2 | [1] | ||
| Structure |
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Download2D MOL
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| Formula |
C36H56O8
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| Canonical SMILES |
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
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| InChI |
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
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| InChIKey |
PHEDXBVPIONUQT-RGYGYFBISA-N
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| CAS Number |
CAS 16561-29-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7569, 139224, 492937, 596579, 3154907, 3288052, 7980341, 11120181, 11120669, 11121157, 11121697, 11122177, 11147264, 11342072, 11362255, 11362778, 11365340, 11367902, 11370807, 11370808, 11373503, 11374437, 11376064, 11404383, 11485638, 11487657, 11489727, 11492704, 14789656, 14838769, 17487166, 22391478, 24278653, 24887446, 24898219, 26613354, 26681074, 26681470, 26755285, 34670407, 46487935, 47290908, 47736218, 47885175, 48034851, 50110884, 53790708, 57244624, 57310548, 57652787
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| ChEBI ID |
CHEBI:37537
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. | |||
| REF 3 | Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. | |||
| REF 4 | Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. | |||
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