Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08PAC
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| Former ID |
DNC004053
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| Drug Name |
L-371257
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| Synonyms |
162042-44-6; L-371257; L-371,257; CHEMBL24781; L 371257; 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one; AC1OCFAC; NCGC00159562-01; SCHEMBL4954712; GTPL2252; CTK8E8747; DTXSID30426072; MolPort-023-276-417; ZINC3824080; BDBM50029649; ABP001011; AKOS024457081; API0009977; KB-78045; 1-[4-[(1-ACETYL-4-PIPERIDINYL)OXY]-2-METHOXYBENZOYL]-4-(2-OXO-2H-3,1-BENZOXAZIN-1(4H)-YL)PIPERIDINE; RT-013479; B7045; L014161; L371,257
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C28H33N3O6
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| Canonical SMILES |
CC(=O)N1CCC(CC1)OC2=CC(=C(C=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5COC4=O)OC
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| InChI |
1S/C28H33N3O6/c1-19(32)29-15-11-22(12-16-29)37-23-7-8-24(26(17-23)35-2)27(33)30-13-9-21(10-14-30)31-25-6-4-3-5-20(25)18-36-28(31)34/h3-8,17,21-22H,9-16,18H2,1-2H3
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| InChIKey |
WDERJSQJYIJOPD-UHFFFAOYSA-N
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| CAS Number |
CAS 162042-44-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Oxytocin receptor (OTR) | Target Info | Inhibitor | [1] |
| Vasopressin V1a receptor (V1AR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| cAMP signaling pathway | ||||
| Oxytocin signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Oxytocin receptor mediated signaling pathway | |||
| Reactome | Vasopressin-like receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Myometrial Relaxation and Contraction Pathways | ||||
| Oxytocin signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. | |||
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