Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08NDE
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| Former ID |
DIB007143
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| Drug Name |
BLZ-945
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| Synonyms |
CSF-1R inhibitor (bone cancer); CSF-1R inhibitor (bone cancer), Novartis
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| Drug Type |
Small molecular drug
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| Indication | Amyotrophic lateral sclerosis [ICD-11: 8B60.0; ICD-9: 335.2] | Phase 2 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Phase 1 | [2] | ||
| Company |
Novartis Institutes for BioMedical Research Inc
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| Structure |
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Download2D MOL |
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| Formula |
C20H22N4O3S
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| Canonical SMILES |
CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O
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| InChI |
1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
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| InChIKey |
ADZBMFGQQWPHMJ-RHSMWYFYSA-N
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| CAS Number |
CAS 953769-46-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Granulocyte colony-stimulating factor receptor (G-CSF-R) | Target Info | Inhibitor | [3] |
| Macrophage colony-stimulating factor 1 receptor (CSF1R) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| MAPK signaling pathway | ||||
| Ras signaling pathway | ||||
| Rap1 signaling pathway | ||||
| Viral protein interaction with cytokine and cytokine receptor | ||||
| Osteoclast differentiation | ||||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04066244) Study of Safety and of the Mechanism of BLZ945 in ALS Patients. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). | |||
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