Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08KAH
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| Drug Name |
Quinazolinedione derivative 3
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| Synonyms |
PMID27841036-Compound-13
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| Drug Type |
Small molecular drug
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| Company |
Janssen Pharmaceutica NV
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H26N4O2
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| Canonical SMILES |
C1CN(CCC1C2=CNC3=CC=CC=C32)CCCN4C5=CC=CC=C5C(=O)NC4=O
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| InChI |
1S/C24H26N4O2/c29-23-19-7-2-4-9-22(19)28(24(30)26-23)13-5-12-27-14-10-17(11-15-27)20-16-25-21-8-3-1-6-18(20)21/h1-4,6-9,16-17,25H,5,10-15H2,(H,26,29,30)
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| InChIKey |
MAJCEXQEEGYUCA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
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