Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07WFK
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| Former ID |
DAP000922
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| Drug Name |
Acetohexamide
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| Synonyms |
Acetohexamid; Acetohexamida; Acetohexamidum; Dimelin; Dimelor; Dymelor; Gamadiabet; Hypoglicil; Metaglucina; Minoral; Ordimel; Tsiklamid; Acetohexamide Lilly Brand; Acetohexamide Salvat Brand; Lilly Brand of Acetohexamide; Ord imel; Salvat Brand of Acetohexamide; U 14812; A-178; Acetohexamida [INN-Spanish]; Acetohexamidum [INN-Latin]; Dimelin (antidiabetic); Dymelor (TN); U-14812; Acetohexamide (JP15/USP/INN); Acetohexamide [USAN:INN:BAN:JAN]; N-(p-Acetylbenzenesulfonyl)-N'-cyclohexylurea; N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea; 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea; 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea; 3-cyclohexyl-1-(p-acetylphenylsulfonyl)urea; 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide; 4-Acetyl-N-[(cyclohexylamino)-carbonyl]benzenesulfonamide; 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; 4-acetyl-N-((cyclohexylamino)carbonyl)benzenesulf onamide
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Approved | [1], [2] | |
| Therapeutic Class |
Hypoglycemic Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H20N2O4S
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| Canonical SMILES |
CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2
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| InChI |
1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
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| InChIKey |
VGZSUPCWNCWDAN-UHFFFAOYSA-N
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| CAS Number |
CAS 968-81-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9025, 4560832, 7847286, 8144406, 8151368, 10321105, 11110689, 11112460, 11466083, 11467203, 11485866, 15347370, 17390067, 17404651, 24278077, 26752942, 29221177, 46505821, 47216939, 47440426, 47662475, 47810929, 48185152, 48413134, 48415505, 48422764, 48424779, 49698323, 49856121, 50105548, 50105549, 50271749, 53777194, 56463352, 57321086, 57653828, 85083217, 85230885, 85787831, 90341130, 92125175, 92303511, 92307991, 99222786, 103590218, 103913586, 104171099, 104299291, 121360822, 121362846
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| ChEBI ID |
CHEBI:28052
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| SuperDrug ATC ID |
A10BB31
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-binding cassette transporter C8 (ABCC8) | Target Info | Modulator | [3] |
| KEGG Pathway | ABC transporters | |||
| Insulin secretion | ||||
| Type II diabetes mellitus | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Pancreas Function | ||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | |||
| Reactome | ABC-family proteins mediated transport | |||
| Regulation of insulin secretion | ||||
| WikiPathways | Potassium Channels | |||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6793). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071893. | |||
| REF 3 | Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Diabetes.2005 Nov;54(11):3065-72. | |||
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