Drug Information
Drug General Information | Top | |||
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Drug ID |
D06TME
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Former ID |
DNCL001684
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Drug Name |
MEDI-546
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Indication | Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 2 | [1], [2] | |
Company |
AstraZeneca
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Target and Pathway | Top | |||
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Target(s) | Interferon alpha/beta receptor 1 (IFNAR1) | Target Info | Modulator | [2] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
PI3K-Akt signaling pathway | ||||
Osteoclast differentiation | ||||
Toll-like receptor signaling pathway | ||||
Jak-STAT signaling pathway | ||||
Natural killer cell mediated cytotoxicity | ||||
Hepatitis C | ||||
Hepatitis B | ||||
Measles | ||||
Influenza A | ||||
Herpes simplex infection | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Pathway Interaction Database | Downstream signaling in naï | |||
Reactome | Interferon alpha/beta signaling | |||
Regulation of IFNA signaling | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
Interferon type I signaling pathways | ||||
Interferon alpha/beta signaling | ||||
Regulation of toll-like receptor signaling pathway | ||||
Osteoclast Signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8258). | |||
REF 2 | Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody. MAbs. 2015;7(2):428-39. |
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