Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06KNK
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| Former ID |
DIB019956
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| Drug Name |
TDZD-8
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| Synonyms |
327036-89-5; 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-; MFCD04973552; NP 01139; AK-48153; 4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione; 1,2,4-Thiadiazolidine-3,5-dione,2-methyl-4-(phenylmethyl)-; GSK-3 Inhibitor I; SCHEMBL139834; GTPL5977; CHEMBL284861; BDBM7781; CTK4G9152; ZINC27361; AOB6176; EX-A109; DTXSID30399590; JDSJDASOXWCHPN-UHFFFAOYSA-N; MolPort-003-844-896; HMS3229G12; A Inhibitor I, TDZD-8
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| Drug Type |
Small molecular drug
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| Indication | Malignant glioma [ICD-11: 2A00.0] | Patented | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H10N2O2S
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| Canonical SMILES |
CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2
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| InChI |
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
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| InChIKey |
JDSJDASOXWCHPN-UHFFFAOYSA-N
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| CAS Number |
CAS 327036-89-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6055436, 8356425, 11108555, 14797987, 26758797, 29217671, 35381791, 47720585, 57356766, 58107448, 76462416, 91610839, 92708299, 99302711, 103192812, 112676838, 124893197, 125580415, 126590965, 134223934, 137232094, 137650937, 152254773, 160833940, 162009856, 162011986, 162248544, 162837469, 163395753, 163688046, 163779005, 163843565, 164836458, 174528910, 175607478, 178102600, 179236131, 184600769, 186014480, 187561549, 202551613, 204394183, 210274741, 210280374, 223366708, 223379791, 223454879, 223519410, 226506996, 242060039
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| ChEBI ID |
CHEBI:147411
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. | |||
| REF 2 | Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3beta inhibitors through virtual screening. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7232-6. | |||
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