Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06IPT
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| Former ID |
DNC009430
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| Drug Name |
N-(Biphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
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| Synonyms |
(2z)-N-Biphenyl-4-Yl-2-Cyano-3-Hydroxybut-2-Enamide; CHEMBL519160; DB07443; (2Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H14N2O2
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| Canonical SMILES |
CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C2=CC=CC=C2)O
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| InChI |
1S/C17H14N2O2/c1-12(20)16(11-18)17(21)19-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,20H,1H3,(H,19,21)/b16-12-
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| InChIKey |
MUVPBAIVOHJDOC-VBKFSLOCSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93. | |||
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