Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05RKT
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| Drug Name |
Pyrazolo[1,5-a]pyrimidine derivative 18
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| Synonyms |
PMID28270010-Compound-Figure11-1
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| Drug Type |
Small molecular drug
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| Company |
ARRAY BIOPHARMA INC. ANDREWS, Steven, Wade CONDROSKI, Kevin, Ronald HAAS, Julia JIANG, Yutong KOLAKOWSKI, Gabrielle, R. SEO, Jeongbeob YANG, Hong-Woon ZHAO, Qian
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| Structure |
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Download2D MOL |
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| Formula |
C19H19FN6O3
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| Canonical SMILES |
C1CC2C3=CC(=CN(C3=O)CC(CNC(=O)C4=C5N=C(N2C1)C=CN5N=C4)O)F
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| InChI |
1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(23-16)14(8-22-26)18(28)21-7-12(27)10-24(9-11)19(13)29/h3,5-6,8-9,12,15,27H,1-2,4,7,10H2,(H,21,28)/t12-,15+/m0/s1
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| InChIKey |
UHWGZELMUUQSBI-SWLSCSKDSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tropomyosin-related kinase A (TrkA) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tropomyosin-related kinase A (TrkA) | Target's Patent Info | [1] | |
| KEGG Pathway | MAPK signaling pathway | |||
| Endocytosis | ||||
| Apoptosis | ||||
| Neurotrophin signaling pathway | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Thyroid cancer | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling | |||
| Reactome | Frs2-mediated activation | |||
| ARMS-mediated activation | ||||
| NGF-independant TRKA activation | ||||
| PI3K/AKT activation | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| BDNF signaling pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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