Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05HUX
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| Former ID |
DNC000776
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| Drug Name |
ICRF-154
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| Synonyms |
Ethyliminum; 1506-47-4; Icrf-154; 1,2-Bis(3,5-dioxopiperazin-1-yl)ethane; UNII-QML51S42CD; QML51S42CD; 4-[2-(3,5-dioxopiperazin-1-yl)ethyl]piperazine-2,6-dione; 4,4'-ethane-1,2-diyldipiperazine-2,6-dione; NSC-129942; NSC 129942; AI3-52846; AC1Q6LVJ; 2, 4,4'-ethylenedi-; AC1L2IM2; salor-int l163228-1ea; SCHEMBL728996; CHEMBL2361164; CTK4C6725; DTXSID40164579; MolPort-002-546-041; GBLIGNUYGOFIKS-UHFFFAOYSA-N; ZINC19367672; NSC129942; STK700954; 2, 4,4'-(1,2-ethanediyl)bis-; AKOS000646070; MCULE-3427635262; API0009072
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C10H14N4O4
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| Canonical SMILES |
C1C(=O)NC(=O)CN1CCN2CC(=O)NC(=O)C2
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| InChI |
1S/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)
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| InChIKey |
GBLIGNUYGOFIKS-UHFFFAOYSA-N
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| CAS Number |
CAS 1506-47-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
420632, 4411092, 8195358, 14971358, 43128836, 57318825, 76442978, 81093067, 90490413, 92714422, 103134857, 104353639, 105193276, 117600768, 117930438, 124896349, 125703789, 126629560, 127929939, 131299819, 135030053, 137066001, 162795043, 164235703, 169681713, 184548213, 198936128, 224879449, 227016967, 241034074, 242574218, 252558454
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. | |||
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