Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05FFR
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| Former ID |
DNC000944
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| Drug Name |
MGBG
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| Synonyms |
MITOGUAZONE; Methyl-Gag; 459-86-9; Methylglyoxal bis(guanylhydrazone); Me-GAG; Methylglyoxal bis(amidinohydrazone); Methyl-G; C5H12N8; Pyruvaldehyde bis(amidinohydrazone); Mitoguazonum; Mitoguazona; CHEMBL216913; CHEBI:43996; Methyl GAG; Mitoguazone [INN:DCF]; Mitoguazonum [INN-Latin]; MGGH; Mitoguazona [INN-Spanish]; (2E,2'E)-2,2'-(1E,2E)-propane-1,2-diylidenedihydrazinecarboximidamide; BRN 1912590; 2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine
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| Drug Type |
Small molecular drug
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| Indication | Head and neck cancer [ICD-11: 2D42] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C5H12N8
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| Canonical SMILES |
CC(=NN=C(N)N)C=NN=C(N)N
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| InChI |
1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
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| InChIKey |
MXWHMTNPTTVWDM-NXOFHUPFSA-N
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| CAS Number |
CAS 459-86-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
611216, 7888899, 12012645, 15195228, 39377781, 49974828, 51091596, 57361327, 77105216, 85301076, 103504484, 103977023, 113903809, 118049580, 124633349, 126591589, 126688706, 131315453, 132511295, 134340069, 134340223, 134340226, 134973137, 136352263, 137241210, 140630209, 164825287, 179225924, 179226390, 179685434, 223442568, 223670665, 226399648, 227917561, 237032998, 241088157, 249691017, 252559424, 252669978
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| ChEBI ID |
CHEBI:43996
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| SuperDrug ATC ID |
L01XX16
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| SuperDrug CAS ID |
cas=000459869
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Inhibitor | [3], [4] |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. | |||
| REF 2 | Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. | |||
| REF 3 | A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601. | |||
| REF 4 | New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity. Cancer Res. 1992 Sep 1;52(17):4712-8. | |||
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