Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03ZFN
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| Former ID |
DIB004485
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| Drug Name |
Tromethamine
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| Synonyms |
Trometamol; 77-86-1; TROMETHAMINE; Tris; Tris(Hydroxymethyl)aminomethane; Tham; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Trizma; Tris buffer; Tris base; Tromethane; Trisaminol; Talatrol; Trispuffer; Trisamin; Pehanorm; Tutofusin tris; Tris-steril; Apiroserum Tham; Addex-tham; Tris-base; Tris, free base; Trimethylolaminomethane; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Tris Amino; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; THAM-E; Tris (buffering agent); Tris(Hydroxymethyl)Aminomethane
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| Drug Type |
Small molecular drug
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| Indication | Acidosis [ICD-11: 5C73; ICD-10: E87.2] | Approved | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C4H11NO3
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| Canonical SMILES |
C(C(CO)(CO)N)O
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| InChI |
1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
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| InChIKey |
LENZDBCJOHFCAS-UHFFFAOYSA-N
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| CAS Number |
CAS 77-86-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9391, 72352, 110795, 219971, 593487, 828157, 832582, 832583, 832595, 854881, 855105, 855120, 3134827, 5276920, 7847462, 7980845, 8006571, 8007086, 8007609, 8007819, 8007821, 8008051, 8008082, 8008083, 8008131, 8008350, 8008504, 8008559, 8008656, 8008907, 8009505, 8009576, 8009611, 8009627, 8009853, 8009941, 8010082, 8010083, 8010137, 8010146, 8010154, 8010391, 8010909, 8010960, 8011128, 8011135, 8011139, 8011161, 8011316, 8011380
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| ChEBI ID |
CHEBI:9754
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| ADReCS Drug ID | BADD_D02302 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Inhibitor | [3] |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7328). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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