Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03QYZ
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| Former ID |
DNC010767
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| Drug Name |
PF-877423
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| Synonyms |
PF-877423; CHEMBL1095047; N-Adamantan-2-Yl-1-Ethyl-D-Prolinamide; SCHEMBL5157584; UJRJQNDIYCDCNX-BAPHQMLMSA-N; BDBM50317209; N-2-adamantyl-1-ethyl-D-prolinamide; (2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carboxamide; (1S,2R)-N-(2-adamantyl)-1-ethyl-pyrrolidine-2-carboxamide; 1-ethyl-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]-D-prolinamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H28N2O
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| Canonical SMILES |
CCN1CCCC1C(=O)NC2C3CC4CC(C3)CC2C4
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| InChI |
1S/C17H28N2O/c1-2-19-5-3-4-15(19)17(20)18-16-13-7-11-6-12(9-13)10-14(16)8-11/h11-16H,2-10H2,1H3,(H,18,20)/t11?,12?,13?,14?,15-,16?/m1/s1
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| InChIKey |
UJRJQNDIYCDCNX-BAPHQMLMSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolism of xenobiotics by cytochrome P450 | ||||
| Metabolic pathways | ||||
| Chemical carcinogenesis | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Pathwhiz Pathway | Steroidogenesis | |||
| Reactome | Glucocorticoid biosynthesis | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. | |||
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