Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03NXV
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| Former ID |
DNC000195
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| Drug Name |
Ametantrone
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| Synonyms |
Ametantrone; 64862-96-0; Ametantrone [INN]; NSC-196473; NSC 196473; Ametantronum [INN-Latin]; Ametantrona [INN-Spanish]; UNII-PNT6041ST1; BRN 2791800; PNT6041ST1; C22H28N4O4; 1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthraquinone; 1,4-Bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione; 9,10-Anthracenedione,1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-; 1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione; 1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione; Ametantronum
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C22H28N4O4
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=C(C=CC(=C3C2=O)NCCNCCO)NCCNCCO
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| InChI |
1S/C22H28N4O4/c27-13-11-23-7-9-25-17-5-6-18(26-10-8-24-12-14-28)20-19(17)21(29)15-3-1-2-4-16(15)22(20)30/h1-6,23-28H,7-14H2
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| InChIKey |
FFGSXKJJVBXWCY-UHFFFAOYSA-N
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| CAS Number |
CAS 64862-96-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Intercalator | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Interactions of antitumor agents Ametantrone and Mitoxantrone (Novatrone) with double-stranded DNA. Biochem Pharmacol. 1985 Dec 15;34(24):4203-13. | |||
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