Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03MNO
|
|||
Former ID |
DNC000849
|
|||
Drug Name |
L-658,758
|
|||
Synonyms |
L-658758; L 658758; L-658,758; CHEMBL446371; L 658,758; (6R-cis)-1-((3-((Acetyloxy)methyl)-7-methoxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-yl)carbonyl)-L-proline S,S-dioxide; 3-Acetoxymethyl-7-methoxy-1-aza-5-thia-8-oxo-bicyclo(4.2.0)oct-2-ene-2-carboxypyrrolidine carboxamide; 116507-04-1; L-Proline, 1-((3-((acetyloxy)methyl)-7-methoxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-yl)carbonyl)-, S,S-dioxide, (6R-cis)-; AC1L3TQJ; SCHEMBL18498419; BDBM50368407; LS-186924; LS-187574; UNII-YMN4MD1ZGQ component SMZXYXKZTNLA
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C16H20N2O9S
|
|||
Canonical SMILES |
CC(=O)OCC1=C(N2C(C(C2=O)OC)S(=O)(=O)C1)C(=O)N3CCCC3C(=O)O
|
|||
InChI |
1S/C16H20N2O9S/c1-8(19)27-6-9-7-28(24,25)15-12(26-2)14(21)18(15)11(9)13(20)17-5-3-4-10(17)16(22)23/h10,12,15H,3-7H2,1-2H3,(H,22,23)/t10-,12-,15+/m0/s1
|
|||
InChIKey |
SMZXYXKZTNLAKY-ITDIGPHOSA-N
|
|||
CAS Number |
CAS 116507-04-1
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [1] |
KEGG Pathway | Transcriptional misregulation in cancer | |||
Systemic lupus erythematosus | ||||
Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
C-MYB transcription factor network | ||||
Reactome | Collagen degradation | |||
Degradation of the extracellular matrix | ||||
Activation of Matrix Metalloproteinases | ||||
WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
Human Complement System | ||||
Degradation of collagen |
References | Top | |||
---|---|---|---|---|
REF 1 | Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.