Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03FVS
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| Former ID |
DCL000332
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| Drug Name |
Salvicine
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| Synonyms |
Salvicine; 240423-23-8; 8-(3,4-dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione; CHEMBL90715; DTXSID50438718; MolPort-028-744-855; AKOS025401738; ( inverted exclamation markA)Salvicine; QC-1122
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 2 | [1] | |
| Company |
Shanghai Institute of Materia Medica (SIMM)
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| Structure |
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Download2D MOL |
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| Formula |
C20H26O4
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| Canonical SMILES |
CC1=C(C2=C(C=C1)C=C(C(=O)C2=O)C(C)C)CCC(C(C)(C)O)O
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| InChI |
1S/C20H26O4/c1-11(2)15-10-13-7-6-12(3)14(17(13)19(23)18(15)22)8-9-16(21)20(4,5)24/h6-7,10-11,16,21,24H,8-9H2,1-5H3
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| InChIKey |
NZIUPDOWWMGNCV-UHFFFAOYSA-N
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| CAS Number |
CAS 240423-23-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [1], [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Salvicine functions as novel topoisomerase II poison by binding to ATP pocket. Mol Pharmacol. 2006 Nov;70(5):1593-601. | |||
| REF 2 | Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation. Acta Pharmacol Sin. 2007 Sep;28(9):1460-5. | |||
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