Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D02SJB
|
|||
Drug Name |
Imidazopyridazine derivative 8
|
|||
Synonyms |
PMID26936077-Compound-46
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Inflammation [ICD-11: 1A00-CA43.1] | Patented | [1] | |
Pain [ICD-11: MG30-MG3Z] | Patented | [1] | ||
Company |
VERTEX PHARMACEUTICALS INCORPORATED
|
|||
Structure |
Download2D MOL |
|||
Formula |
C27H31FN8O2
|
|||
Canonical SMILES |
CC1=NC(=NN1)C(=O)N2CCN(C(C2)(C)C)C(=O)C3=CN4C(=N3)C(=CC(=N4)C5=CC=C(C=C5)F)C(C)(C)C
|
|||
InChI |
1S/C27H31FN8O2/c1-16-29-22(32-31-16)25(38)34-11-12-35(27(5,6)15-34)24(37)21-14-36-23(30-21)19(26(2,3)4)13-20(33-36)17-7-9-18(28)10-8-17/h7-10,13-14H,11-12,15H2,1-6H3,(H,29,31,32)
|
|||
InChIKey |
DWEGVIUHJKAMGX-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Proteinase activated receptor 2 (PAR2) | Target Info | Antagonist | [1] |
Target's Patent Info | Proteinase activated receptor 2 (PAR2) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
African trypanosomiasis | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.