Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02RTS
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| Former ID |
DIB019149
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| Drug Name |
citric acid
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| Synonyms |
Citric acid; 77-92-9; Citric acid, anhydrous; citrate; Citro; Anhydrous citric acid; Aciletten; Citretten; Chemfill; Hydrocerol A; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-; Kyselina citronova; 2-hydroxy-1,2,3-propanetricarboxylic acid; 2-Hydroxytricarballylic acid; Citric acid anhydrous; Caswell No 221C; F 0001 (polycarboxylic acid); 3-Carboxy-3-hydroxypentane-1,5-dioic acid; 2-Hydroxypropanetricarboxylic acid; beta-Hydroxytricarballylic acid; FEMA Number 2306; K-Lyte
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H8O7
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| Canonical SMILES |
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
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| InChI |
1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
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| InChIKey |
KRKNYBCHXYNGOX-UHFFFAOYSA-N
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| CAS Number |
CAS 77-92-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3458, 89571, 493004, 583624, 583626, 583628, 583666, 583709, 583750, 583782, 583785, 583920, 583952, 583961, 583962, 583990, 584046, 584048, 584050, 584052, 584054, 584057, 584096, 584098, 584199, 584208, 584526, 584546, 584681, 584697, 584768, 584772, 585348, 585511, 585681, 585694, 587788, 607173, 819959, 820166, 820611, 820613, 820722, 820723, 820726, 820754, 820758, 820760, 820762, 820764
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| ChEBI ID |
CHEBI:30769
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| ADReCS Drug ID | BADD_D00477 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Binder | [2] |
| Polycystic kidney disease 2-like 1 (TRPP2) | Target Info | Activator | [3] | |
| Transient receptor potential cation channel V4 (TRPV4) | Target Info | Activator | [4] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2478). | |||
| REF 2 | Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative. Antimicrob Agents Chemother. 2004 Apr;48(4):1256-71. | |||
| REF 3 | Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. | |||
| REF 4 | Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8. | |||
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