Drug Information
Drug General Information | Top | |||
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Drug ID |
D02FMR
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Former ID |
DNC014286
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Drug Name |
6-bromo-N-(3-chlorophenyl)quinazolin-4-amine
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Synonyms |
6-bromo-N-(3-chlorophenyl)quinazolin-4-amine; CHEMBL1079374; AC1LEZQW; C14H9BrClN3; ChemDiv1_028574; Oprea1_590274; Neuro1_000364; MLS000572427; cid_720635; SCHEMBL4783154; HMS668C18; MolPort-000-660-268; ZINC122236; HMS2493B23; BDBM50311887; STK965864; AKOS002348868; MCULE-5418328745; SMR000194385; EU-0077259; ST50477345; 6-bromo-N-(3-chlorophenyl)-4-quinazolinamine; (6-bromoquinazolin-4-yl)(3-chlorophenyl)amine; SR-01000485096; SR-01000485096-1
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C14H9BrClN3
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Canonical SMILES |
C1=CC(=CC(=C1)Cl)NC2=NC=NC3=C2C=C(C=C3)Br
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InChI |
1S/C14H9BrClN3/c15-9-4-5-13-12(6-9)14(18-8-17-13)19-11-3-1-2-10(16)7-11/h1-8H,(H,17,18,19)
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InChIKey |
LYKXFKUSOXETGV-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 1 (mGluR1) | Target Info | Inhibitor | [1] |
Metabotropic glutamate receptor 5 (mGluR5) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
FoxO signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Gap junction | ||||
Long-term potentiation | ||||
Retrograde endocannabinoid signaling | ||||
Glutamatergic synapse | ||||
Long-term depression | ||||
Estrogen signaling pathway | ||||
Huntington's disease | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
Metabotropic glutamate receptor group III pathway | ||||
Metabotropic glutamate receptor group I pathway | ||||
Endogenous cannabinoid signaling | ||||
Reactome | G alpha (q) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | Hypothetical Network for Drug Addiction | |||
GPCRs, Class C Metabotropic glutamate, pheromone | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. |
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