Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02ESK
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| Former ID |
DIB000654
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| Drug Name |
GSK-732461
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| Synonyms |
HIV vaccine (gag, pol, nef), GSK; HIV vaccine (gag, pol, nef), GlaxoSmithKline; 732461; 732462
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| Drug Type |
Vaccine
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Discontinued in Phase 2 | [1] | |
| Company |
GlaxoSmithKline plc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus GAG protein (HIV gag) | Target Info | . | [2] |
| Human immunodeficiency virus Negative factor (HIV nef) | Target Info | . | [2] | |
| Reactome | Uncoating of the HIV Virion | |||
| Budding and maturation of HIV virion | ||||
| Integration of provirus | ||||
| Early Phase of HIV Life Cycle | ||||
| Minus-strand DNA synthesis | ||||
| Plus-strand DNA synthesis | ||||
| 2-LTR circle formation | ||||
| Binding and entry of HIV virion | ||||
| Membrane binding and targetting of GAG proteins | ||||
| Assembly Of The HIV Virion | ||||
| Integration of viral DNA into host genomic DNA | ||||
| Autointegration results in viral DNA circles | ||||
| APOBEC3G mediated resistance to HIV-1 infection | ||||
| Vpr-mediated nuclear import of PICs | ||||
| WikiPathways | Host Interactions of HIV factors | |||
| HIV Life Cycle | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027409) | |||
| REF 2 | Preventive technologies, research toward a cure, and immune-based and gene therapies. HIV Treatment Bulletin. 30 June 2013. | |||
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