Drug Information
Drug General Information | Top | |||
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Drug ID |
D02CQW
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Former ID |
DNC006698
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Drug Name |
H-D-Phe-c[Cys-Ala-D-Trp-Lys-Thr-Cys]-Thr-NH2
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Synonyms |
CHEMBL376703; H-D-Phe-c[Cys-Ala-D-Trp-Lys-Thr-Cys]-Thr-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C43H61N11O10S2
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Canonical SMILES |
CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CC2=CC=CC=C2)N)C(=O)NC(C(C)O)C(=O)N)C(C)O)CCCCN)CC3=CNC4=CC=CC=C43
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InChI |
1S/C43H61N11O10S2/c1-22-37(58)50-31(18-26-19-47-29-14-8-7-13-27(26)29)40(61)49-30(15-9-10-16-44)39(60)54-35(24(3)56)43(64)52-33(42(63)53-34(23(2)55)36(46)57)21-66-65-20-32(41(62)48-22)51-38(59)28(45)17-25-11-5-4-6-12-25/h4-8,11-14,19,22-24,28,30-35,47,55-56H,9-10,15-18,20-21,44-45H2,1-3H3,(H2,46,57)(H,48,62)(H,49,61)(H,50,58)(H,51,59)(H,52,64)(H,53,63)(H,54,60)/t22-,23+,24+,28+,30-,31+,32-,33-,34-,35-/m0/s1
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InChIKey |
DNIBTKHTGSPUNA-RHSAGAAYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Somatostatin receptor type 2 (SSTR2) | Target Info | Inhibitor | [1] |
Somatostatin receptor type 3 (SSTR3) | Target Info | Inhibitor | [1] | |
Somatostatin receptor type 5 (SSTR5) | Target Info | Inhibitor | [1] | |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gastric acid secretion | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
GPCRs, Class A Rhodopsin-like | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. |
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