Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02AIM
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| Former ID |
DCL000304
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| Drug Name |
Metoprine
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| Synonyms |
METOPRINE; Methodichlorophen; DDMP; 7761-45-7; Metoprine [USAN]; BW-197U; TCMDC-123931; NSC-19494; SK 5265; 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE; U 197; NSC7364; U-197; UNII-2L9RKX796Q; Metoprine (USAN); BW 50-197; METOPRINE, METHODICHLOROPHEN; 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; NSC 7364; 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-; NSC 19494; BW50197; BRN 0223622; 5-(3,4-Dichlorphenyl)-6-methyl-2,4-pyrimidindiamin; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; MLS002701892; DDMP; BW 197 U; BW 1970; BW 197U; BW 50197; BW 50,197; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine; Chloroaniline 1
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| Drug Type |
Small molecular drug
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| Indication | Advanced cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-C96; ICD-9: 140-229] | Phase 2 | [1], [2] | |
| Company |
Werkheiser
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H10Cl2N4
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| Canonical SMILES |
CC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl
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| InChI |
1S/C11H10Cl2N4/c1-5-9(10(14)17-11(15)16-5)6-2-3-7(12)8(13)4-6/h2-4H,1H3,(H4,14,15,16,17)
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| InChIKey |
VQJHOPSWBGJHQS-UHFFFAOYSA-N
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| CAS Number |
CAS 7761-45-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
73253, 82389, 602547, 7611890, 7847375, 7886431, 8026862, 8136917, 8167867, 11445962, 11446882, 14848327, 24714896, 29291534, 46393826, 46504679, 47217117, 50035975, 50971542, 57331733, 84974635, 85858390, 92763928, 103224661, 103955731, 104359914, 117418166, 124633328, 125434045, 126729571, 129512013, 134224754, 134338960, 134339850, 134990138, 137184701, 137241183, 142971122, 152133986, 160967647, 163884598, 164763044, 170466776, 178103984, 179151147, 187071961, 198935081, 223681386, 226395808, 241145375
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine N-methyltransferase (HNMT) | Target Info | Inhibitor | [3] |
| Polypeptide deformylase (PDF) | Target Info | Inhibitor | [4] | |
| BioCyc | Histamine degradation | |||
| KEGG Pathway | Histidine metabolism | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Histidine Metabolism | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| WikiPathways | Methylation Pathways | |||
| Metapathway biotransformation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7412). | |||
| REF 2 | ClinicalTrials.gov (NCT01579110) Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.. U.S. National Institutes of Health. | |||
| REF 3 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||
| REF 4 | Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. | |||
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