Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02ACL
|
|||
| Former ID |
DIB018958
|
|||
| Drug Name |
benzamil
|
|||
| Synonyms |
Benzamil; 2898-76-2; UNII-04659UUJ94; N-(N-Benzylamidino)-3,5-diamino-6-chloropyrazine carboxamide; GNF-Pf-192; CHEMBL212579; CHEBI:34558; 04659UUJ94; 3,5-Diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)pyrazinecarboxamide; 3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)-; Spectrum3_001823; Prestwick1_000657; Prestwick3_000657; Prestwick2_000657; Prestwick0_000657; Lopac-B-2417; AC1L33CQ; Lopac0_000211; KBioGR_000300
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C13H14ClN7O
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
|
|||
| InChI |
1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)
|
|||
| InChIKey |
KXDROGADUISDGY-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 2898-76-2
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
586340, 621649, 4997149, 11110839, 11110840, 11120241, 11120729, 11121217, 11121645, 11122125, 11336176, 11361415, 11362714, 11365276, 11367838, 11370699, 11370700, 11373064, 11373439, 11376000, 11462387, 11466685, 11467805, 11486350, 11491638, 15248269, 26755660, 26755661, 44437002, 47870415, 47870416, 48019678, 48019679, 48095241, 48244091, 48318723, 48319195, 48319196, 48394633, 49698609, 50068048, 50110974, 50110975, 50686741, 53849316, 57338445, 85787710, 85787961, 90341795, 92309106
|
|||
| ChEBI ID |
CHEBI:34558
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acid-sensing ion channel 3 (ASIC3) | Target Info | Blocker (channel blocker) | [2] |
| Amiloride-sensitive sodium channel (ENaC) | Target Info | Blocker (channel blocker) | [3] | |
| Polycystic kidney disease 2-like 1 (TRPP2) | Target Info | Blocker (channel blocker) | [4] | |
| KEGG Pathway | Taste transduction | |||
| Aldosterone-regulated sodium reabsorption | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Pathwhiz Pathway | Kidney Function | |||
| Reactome | Stimuli-sensing channels | |||
| WikiPathways | Nuclear Receptors Meta-Pathway | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4145). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 684). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 742). | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.