Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00VZF
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| Former ID |
DIB007605
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| Drug Name |
Merbarone
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| Synonyms |
NSC-336628
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| Drug Type |
Small molecular drug
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| Indication | Pancreatic cancer [ICD-11: 2C10] | Discontinued in Phase 2 | [1] | |
| Company |
Uniroyal Chemical Co Inc
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| Structure |
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Download2D MOL |
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| Formula |
C11H9N3O3S
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| Canonical SMILES |
C1=CC=C(C=C1)NC(=O)C2C(=O)NC(=S)NC2=O
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| InChI |
1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
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| InChIKey |
JARCFMKMOFFIGZ-UHFFFAOYSA-N
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| CAS Number |
CAS 97534-21-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000894) | |||
| REF 2 | The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res. 2012 Oct-Nov;738-739:45-51. | |||
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