| Target and Pathway |
Top |
| Target(s) |
Angiopoietin 1 receptor (TEK) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 1 (CDK1) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 2 (CDK2) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 4 (CDK4) |
Target Info
|
Inhibitor |
[1] |
| Cyclin-dependent kinase 6 (CDK6) |
Target Info
|
Inhibitor |
[1] |
| Epidermal growth factor receptor (EGFR) |
Target Info
|
Inhibitor |
[1] |
| ERBB2 messenger RNA (HER2 mRNA) |
Target Info
|
Inhibitor |
[1] |
| G1/S-specific cyclin-D1 (CCND1) |
Target Info
|
Inhibitor |
[1] |
| G1/S-specific cyclin-E1 (CCNE1) |
Target Info
|
Inhibitor |
[1] |
| G2/mitotic-specific cyclin B1 (CCNB1) |
Target Info
|
Inhibitor |
[1] |
| Protein kinase C alpha (PRKCA) |
Target Info
|
Inhibitor |
[1] |
| Protein kinase C epsilon (PRKCE) |
Target Info
|
Inhibitor |
[1] |
| Protein kinase C gamma (PRKCG) |
Target Info
|
Inhibitor |
[1] |
| Vascular endothelial growth factor receptor 2 (KDR) |
Target Info
|
Inhibitor |
[1] |
|
KEGG Pathway
|
Cell cycle
|
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Hepatitis B
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Measles
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Pathways in cancer
|
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Viral carcinogenesis
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MicroRNAs in cancer
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Pancreatic cancer
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Glioma
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Melanoma
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Chronic myeloid leukemia
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Small cell lung cancer
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Non-small cell lung cancer
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Oocyte meiosis
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Prostate cancer
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Gap junction
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Progesterone-mediated oocyte maturation
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Herpes simplex infection
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Epstein-Barr virus infection
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FoxO signaling pathway
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AMPK signaling pathway
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Wnt signaling pathway
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Hippo signaling pathway
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Focal adhesion
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Jak-STAT signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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HTLV-I infection
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Proteoglycans in cancer
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Colorectal cancer
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Endometrial cancer
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Thyroid cancer
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Bladder cancer
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Acute myeloid leukemia
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Viral myocarditis
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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HIF-1 signaling pathway
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Phosphatidylinositol signaling system
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Sphingolipid signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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VEGF signaling pathway
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Tight junction
|
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Natural killer cell mediated cytotoxicity
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Fc gamma R-mediated phagocytosis
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Leukocyte transendothelial migration
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
|
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GABAergic synapse
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Dopaminergic synapse
|
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Long-term depression
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Inflammatory mediator regulation of TRP channels
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Insulin secretion
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Melanogenesis
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Thyroid hormone synthesis
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Aldosterone-regulated sodium reabsorption
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Endocrine and other factor-regulated calcium reabsorption
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretion
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Amphetamine addiction
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Morphine addiction
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Vibrio cholerae infection
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African trypanosomiasis
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Amoebiasis
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Choline metabolism in cancer
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Cytokine-cytokine receptor interaction
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Endocytosis
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Adrenergic signaling in cardiomyocytes
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Fc epsilon RI signaling pathway
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GnRH signaling pathway
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Pathogenic Escherichia coli infection
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Influenza A
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Rheumatoid arthritis
|
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T cell receptor signaling pathway
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Dorso-ventral axis formation
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Adherens junction
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Regulation of actin cytoskeleton
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Estrogen signaling pathway
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Epithelial cell signaling in Helicobacter pylori infection
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Hepatitis C
|
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Central carbon metabolism in cancer
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cGMP-PKG signaling pathway
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Type II diabetes mellitus
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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IL2 Signaling Pathway
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TCR Signaling Pathway
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RANKL Signaling Pathway
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EGFR1 Signaling Pathway
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Notch Signaling Pathway
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Wnt Signaling Pathway
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IL4 Signaling Pathway
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Panther Pathway
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Cell cycle
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Parkinson disease
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p53 pathway
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p53 pathway feedback loops 2
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PI3 kinase pathway
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Wnt signaling pathway
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CCKR signaling map ST
|
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Alpha adrenergic receptor signaling pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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VEGF signaling pathway
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5HT2 type receptor mediated signaling pathway
|
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Histamine H1 receptor mediated signaling pathway
|
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Oxytocin receptor mediated signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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PDGF signaling pathway
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
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Cadherin signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Pathwhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
|
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Activation of PKC through G protein coupled receptor
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Phosphatidylinositol Phosphate Metabolism
|
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Pathway Interaction Database
|
p73 transcription factor network
|
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Coregulation of Androgen receptor activity
|
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C-MYB transcription factor network
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IL2 signaling events mediated by STAT5
|
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Regulation of retinoblastoma protein
|
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Signaling events mediated by PRL
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E2F transcription factor network
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mTOR signaling pathway
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FOXM1 transcription factor network
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BARD1 signaling events
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PLK3 signaling events
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PLK1 signaling events
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AP-1 transcription factor network
|
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Retinoic acid receptors-mediated signaling
|
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Notch signaling pathway
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
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Presenilin action in Notch and Wnt signaling
|
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Integrin-linked kinase signaling
|
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Regulation of Telomerase
|
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E-cadherin signaling in the nascent adherens junction
|
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ATF-2 transcription factor network
|
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Neurotrophic factor-mediated Trk receptor signaling
|
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Validated nuclear estrogen receptor alpha network
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Signaling mediated by p38-gamma and p38-delta
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
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Validated targets of C-MYC transcriptional repression
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
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Signaling events mediated by focal adhesion kinase
|
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Endothelins
|
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Thromboxane A2 receptor signaling
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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IL8- and CXCR2-mediated signaling events
|
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PAR1-mediated thrombin signaling events
|
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IL8- and CXCR1-mediated signaling events
|
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HIF-2-alpha transcription factor network
|
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Beta3 integrin cell surface interactions
|
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Signaling events mediated by TCPTP
|
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SHP2 signaling
|
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S1P1 pathway
|
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VEGF and VEGFR signaling network
|
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Integrins in angiogenesis
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Notch-mediated HES/HEY network
|
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TCR signaling in naï
|
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|
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Canonical NF-kappaB pathway
|
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Signaling events regulated by Ret tyrosine kinase
|
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TCR signaling in naï
|
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|
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Ras signaling in the CD4+ TCR pathway
|
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ErbB1 downstream signaling
|
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Syndecan-4-mediated signaling events
|
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PDGFR-beta signaling pathway
|
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VEGFR1 specific signals
|
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a6b1 and a6b4 Integrin signaling
|
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Regulation of Ras family activation
|
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Downstream signaling in naï
|
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Angiopoietin receptor Tie2-mediated signaling
|
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Regulation of nuclear SMAD2/3 signaling
|
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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Validated targets of C-MYC transcriptional activation
|
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ATR signaling pathway
|
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IL2-mediated signaling events
|
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FoxO family signaling
|
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p53 pathway
|
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LPA receptor mediated events
|
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Signaling events mediated by PTP1B
|
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Arf6 signaling events
|
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EGF receptor (ErbB1) signaling pathway
|
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EGFR-dependent Endothelin signaling events
|
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Posttranslational regulation of adherens junction stability and dissassembly
|
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Direct p53 effectors
|
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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E-cadherin signaling in keratinocytes
|
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ErbB receptor signaling network
|
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Internalization of ErbB1
|
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Stabilization and expansion of the E-cadherin adherens junction
|
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Syndecan-3-mediated signaling events
|
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ErbB4 signaling events
|
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ErbB2/ErbB3 signaling events
|
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LPA4-mediated signaling events
|
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CDC42 signaling events
|
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Reactome
|
Oxidative Stress Induced Senescence
|
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Senescence-Associated Secretory Phenotype (SASP)
|
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Oncogene Induced Senescence
|
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Cyclin D associated events in G1
|
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E2F mediated regulation of DNA replication
|
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G0 and Early G1
|
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SCF(Skp2)-mediated degradation of p27/p21
|
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DNA Damage/Telomere Stress Induced Senescence
|
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Cyclin E associated events during G1/S transition
|
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G1/S-Specific Transcription
|
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p53-Dependent G1 DNA Damage Response
|
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MAPK3 (ERK1) activation
|
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Cyclin B2 mediated events
|
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Golgi Cisternae Pericentriolar Stack Reorganization
|
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
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Regulation of APC/C activators between G1/S and early anaphase
|
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Phosphorylation of the APC/C
|
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Phosphorylation of Emi1
|
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Condensation of Prophase Chromosomes
|
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MASTL Facilitates Mitotic Progression
|
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Resolution of Sister Chromatid Cohesion
|
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Condensation of Prometaphase Chromosomes
|
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Regulation of PLK1 Activity at G2/M Transition
|
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Activation of NIMA Kinases NEK9, NEK6, NEK7
|
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Loss of Nlp from mitotic centrosomes
|
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Recruitment of mitotic centrosome proteins and complexes
|
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Loss of proteins required for interphase microtubule organization?from the centrosome
|
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Recruitment of NuMA to mitotic centrosomes
|
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Depolymerisation of the Nuclear Lamina
|
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Anchoring of the basal body to the plasma membrane
|
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MAPK6/MAPK4 signaling
|
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Cyclin A/B1 associated events during G2/M transition
|
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G2/M DNA replication checkpoint
|
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
|
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Pre-NOTCH Transcription and Translation
|
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RMTs methylate histone arginines
|
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Ubiquitin-dependent degradation of Cyclin D1
|
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Calmodulin induced events
|
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Disinhibition of SNARE formation
|
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Trafficking of GluR2-containing AMPA receptors
|
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G alpha (z) signalling events
|
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WNT5A-dependent internalization of FZD4
|
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Response to elevated platelet cytosolic Ca2+
|
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Neurophilin interactions with VEGF and VEGFR
|
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VEGF binds to VEGFR leading to receptor dimerization
|
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Integrin cell surface interactions
|
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EPHA-mediated growth cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated cell proliferation
|
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Regulation of KIT signaling
|
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EGFR Transactivation by Gastrin
|
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Inactivation, recovery and regulation of the phototransduction cascade
|
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Syndecan interactions
|
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Acetylcholine regulates insulin secretion
|
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Ca2+ pathway
|
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HuR (ELAVL1) binds and stabilizes mRNA
|
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Tie2 Signaling
|
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RAF/MAP kinase cascade
|
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Transcriptional regulation of white adipocyte differentiation
|
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Meiotic recombination
|
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Activation of ATR in response to replication stress
|
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Processing of DNA double-strand break ends
|
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G2 Phase
|
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Orc1 removal from chromatin
|
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Cyclin A:Cdk2-associated events at S phase entry
|
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Factors involved in megakaryocyte development and platelet production
|
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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
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SHC1 events in ERBB2 signaling
|
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PLCG1 events in ERBB2 signaling
|
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PIP3 activates AKT signaling
|
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GRB2 events in EGFR signaling
|
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GAB1 signalosome
|
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SHC1 events in EGFR signaling
|
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EGFR downregulation
|
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GRB2 events in ERBB2 signaling
|
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PI3K events in ERBB2 signaling
|
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Constitutive Signaling by Aberrant PI3K in Cancer
|
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Constitutive Signaling by EGFRvIII
|
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Polo-like kinase mediated events
|
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Sema4D induced cell migration and growth-cone collapse
|
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Effects of PIP2 hydrolysis
|
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DAG and IP3 signaling
|
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Role of phospholipids in phagocytosis
|
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WikiPathways
|
DNA Damage Response
|
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G1 to S cell cycle control
|
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Wnt Signaling Pathway Netpath
|
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Retinoblastoma (RB) in Cancer
|
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Signaling Pathways in Glioblastoma
|
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Metastatic brain tumor
|
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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Mitotic G1-G1/S phases
|
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Cell Cycle
|
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miRNAs involved in DNA damage response
|
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miRNA Regulation of DNA Damage Response
|
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ID signaling pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Parkinsons Disease Pathway
|
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Parkin-Ubiquitin Proteasomal System pathway
|
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TSH signaling pathway
|
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Androgen receptor signaling pathway
|
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TGF beta Signaling Pathway
|
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PPAR Alpha Pathway
|
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MAP kinase activation in TLR cascade
|
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RAF/MAP kinase cascade
|
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Mitotic Prophase
|
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Mitotic Prometaphase
|
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BMI1
|
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ATM Signaling Pathway
|
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Spinal Cord Injury
|
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Prostate Cancer
|
|
Regulation of Microtubule Cytoskeleton
|
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Integrated Cancer pathway
|
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Mitotic G2-G2/M phases
|
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APC/C-mediated degradation of cell cycle proteins
|
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Cell Cycle Checkpoints
|
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DNA Damage Response (only ATM dependent)
|
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Notch Signaling Pathway
|
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Wnt Signaling Pathway and Pluripotency
|
|
Copper homeostasis
|
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Focal Adhesion
|
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Mesodermal Commitment Pathway
|
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Hair Follicle Development: Organogenesis (Part 2 of 3)
|
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Bladder Cancer
|
|
Pre-NOTCH Expression and Processing
|
|
S Phase
|
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Polycystic Kidney Disease Pathway
|
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IL-7 Signaling Pathway
|
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Leptin signaling pathway
|
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Integrated Breast Cancer Pathway
|
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Calcium Regulation in the Cardiac Cell
|
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Wnt Signaling Pathway
|
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MAPK Signaling Pathway
|
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G Protein Signaling Pathways
|
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Myometrial Relaxation and Contraction Pathways
|
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DAG and IP3 signaling
|
|
miRs in Muscle Cell Differentiation
|
|
Opioid Signalling
|
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Response to elevated platelet cytosolic Ca2+
|
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Nifedipine Activity
|
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Cardiac Progenitor Differentiation
|
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Signaling by VEGF
|
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Angiogenesis
|
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ErbB Signaling Pathway
|
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Insulin Signaling
|
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EGF/EGFR Signaling Pathway
|
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Kit receptor signaling pathway
|
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Transcriptional activation by NRF2
|
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Human Complement System
|
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Cardiac Hypertrophic Response
|
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Syndecan interactions
|
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
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Signaling by SCF-KIT
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
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Alpha 6 Beta 4 signaling pathway
|
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Oncostatin M Signaling Pathway
|
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
|
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Pathogenic Escherichia coli infection
|
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Endothelin Pathways
|
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FSH signaling pathway
|
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Integration of energy metabolism
|
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TOR Signaling
|
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Cell surface interactions at the vascular wall
|
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Ovarian Infertility Genes
|
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Transcriptional Regulation of White Adipocyte Differentiation
|
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Meiotic Recombination
|
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DNA Replication
|
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M/G1 Transition
|
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Aryl Hydrocarbon Receptor
|
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Synthesis of DNA
|
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Regulation of DNA replication
|
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Factors involved in megakaryocyte development and platelet production
|
|
Regulation of Actin Cytoskeleton
|
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Aryl Hydrocarbon Receptor Pathway
|
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Extracellular vesicle-mediated signaling in recipient cells
|
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
|
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Signaling by ERBB4
|
|
Signaling by ERBB2
|
|
PIP3 activates AKT signaling
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Gastric cancer network 2
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Signaling by EGFR
|
|
L1CAM interactions
|
|
AMPK Signaling
|
|
Semaphorin interactions
|
|
Hypothetical Network for Drug Addiction
|
|
GPCR downstream signaling
|
|
Effects of PIP2 hydrolysis
|
|
Physiological and Pathological Hypertrophy of the Heart
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