Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00NNC
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| Former ID |
DAP000827
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| Drug Name |
Etidronic acid
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| Synonyms |
EHDP; Etidronate; Etidronsaeure; HEDP; Osteoscan; Acetodiphosphonic acid; Acide etidronique; Acido etidronico; Acidumetidronicum; Didronel IV; Etidronic acid monohydrate; Hydroxyethanediphosphonic acid; Oxyethylidenediphosphonic acid; Turpinal SL; Dequest2010; Dequest 2015; Dequest Z 010; Ferrofos 510; RP 61; Acide etidronique [INN-French]; Acido etidronico [INN-Spanish]; Acidum etidronicum [INN-Latin]; Diphosphonate (base); Etidronic acid (USAN/INN); Etidronic acid [USAN:INN:BAN]; Hydroxyethane-1,1-diphosphonic acid; Ethane-1-hydroxy-1,1-bisphosphonate; Ethane-1-hydroxy-1,1-bisphosphonic acid; Ethane-1-hydroxy-1,1-diphosphonate; Ethane-1-hydroxy-1,1-diphosphonic acid; Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester; (1-Hydroxyethylene)diphosphonic acid; (1-Hydroxyethylidene)bis(phosphonic acid); (1-Hydroxyethylidene)bisphosphonic acid; (1-Hydroxyethylidene)diphoshonic acid; (1-Hydroxyethylidene)diphosphonic acid; (1-hydroxy-1-phosphonoethyl)phosphonic acid; (1-hydroxyethane-1,1-diyl)bis(phosphonic acid); (Hydroxyethylidene)diphosphonic acid; 1,1,1-Ethanetriol diphosphonate; 1-HYDROXY-1,1-DIPHOSPHONOETHANE; 1-Hydroxyethane-1,1,-diphosphonic acid; 1-Hydroxyethane-1,1-bisphosphonic acid; 1-Hydroxyethane-1,1-diphosphonate; 1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethanediphosphonic acid; 1-Hydroxyethylidene 1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-biphosphonate; 1-Hydroxyethylidene-1,1-bisphosphonate; 1-Hydroxyethylidene-1,1-diphosphonic acid; 1-Hydroxyethylidenediphosphonic acid; 1000SL
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| Drug Type |
Small molecular drug
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| Indication | Paget's disease [ICD-11: FB85; ICD-9: 731] | Approved | [1], [2] | |
| Therapeutic Class |
Bone Density Conservation Agents
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| Structure |
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Download2D MOL |
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| Formula |
C2H8O7P2
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| Canonical SMILES |
CC(O)(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
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| InChIKey |
DBVJJBKOTRCVKF-UHFFFAOYSA-N
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| CAS Number |
CAS 2809-21-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9938, 132168, 626344, 5268197, 7849432, 8152103, 11466891, 11468011, 11486562, 14797598, 24878684, 24895766, 29215269, 29222442, 46507694, 47365358, 47515472, 47959932, 48110605, 48415987, 48417898, 50007630, 50587317, 53789362, 57321717, 57651468, 57654267, 81093251, 85175936, 87570971, 93576729, 93576926, 98461899, 103228758, 104009084, 104303122, 111978152, 117823194, 124892103, 124892104, 125346884, 126655223, 126674414, 126730500, 127711966, 131349600, 131806666, 134338107, 134340010, 134983248
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| ChEBI ID |
CHEBI:4907
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| ADReCS Drug ID | BADD_D00849 | |||
| SuperDrug ATC ID |
M05BA01
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein-tyrosine phosphatase sigma (R-PTP-sigma) | Target Info | Inhibitor | [3] |
| Reactome | ECM proteoglycans | |||
| WikiPathways | Extracellular matrix organization | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7184). | |||
| REF 2 | Drug information of Didronel, 2008. eduDrugs. | |||
| REF 3 | Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. J Bone Miner Res. 1996 Apr;11(4):535-43. | |||
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