Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00FMV
|
|||
| Former ID |
DNC002640
|
|||
| Drug Name |
Putrescine
|
|||
| Synonyms |
putrescine; 1,4-diaminobutane; 1,4-butanediamine; butane-1,4-diamine; 110-60-1; tetramethylenediamine; Butylenediamine; Putrescin; 1,4-Butylenediamine; Tetramethyldiamine; 1,4-Tetramethylenediamine; putrescina; Putreszin; Tetramethylendiamin; UNII-V10TVZ52E4; NSC 60545; BRN 0605282; H2N(CH2)4NH2; CCRIS 6751; AI3-25444; 1,4-Diamino-n-butane; EINECS 203-782-3; 1,4-Diaminobutane, 99%; CHEMBL46257; V10TVZ52E4; CHEBI:17148; KIDHWZJUCRJVML-UHFFFAOYSA-N; MFCD00008235; 1,4-butanediammonium; Diaminobutane dihydrochloride; PUT; HSDB 7865
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Burn and burn infection [ICD-11: ND90-NE2Z; ICD-10: A00-B99; ICD-9: 001-139] | Discontinued in Phase 2 | [1], [2] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C4H12N2
|
|||
| Canonical SMILES |
C(CCN)CN
|
|||
| InChI |
1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
|
|||
| InChIKey |
KIDHWZJUCRJVML-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 110-60-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
3434, 5825, 108539, 588366, 629781, 826882, 838778, 3132664, 7437577, 7890110, 8143681, 8150940, 10503860, 11111663, 11335891, 11361130, 11364540, 11367102, 11369664, 11372474, 11374072, 11377826, 11408821, 11462102, 11485705, 11489751, 11491013, 11492052, 11495460, 11537956, 15194199, 17436306, 24859702, 24859703, 24893255, 26702290, 26707434, 35229592, 38337057, 46261202, 46391410, 46392188, 46392191, 46506728, 47662300, 47959763, 48259246, 48259247, 49748476, 49895575
|
|||
| ChEBI ID |
CHEBI:17148
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ornithine decarboxylase (ODC1) | Target Info | Inhibitor | [3] |
| S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Inhibitor | [3] | |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| Putrescine biosynthesis I | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Ornithine degradation | |||
| CCKR signaling map ST | ||||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2388). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013366) | |||
| REF 3 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.