Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VC0I
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| Former ID |
DNC001076
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| Drug Name |
Oxindole 94
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| Synonyms |
SB 202190; 152121-30-7; SB202190; SB-202190; FHPI; SB202190 (FHPI); UNII-PVX798P8GI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; PVX798P8GI; SB 202190, Immobilized; C20H14FN3O; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H14FN3O
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| Canonical SMILES |
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
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| InChI |
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
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| InChIKey |
QHKYPYXTTXKZST-UHFFFAOYSA-N
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| CAS Number |
CAS 152121-30-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
647319, 4331462, 7953022, 11111814, 11114007, 11120359, 11120847, 11121335, 11121738, 11122218, 11362860, 11365422, 11367984, 11370931, 11370932, 11373585, 11376146, 14875241, 16770907, 17404736, 24262977, 24278272, 26752145, 26752146, 26759477, 26759482, 26759487, 37494338, 39379797, 46516044, 47349352, 47364985, 47736256, 48110249, 48169360, 48334264, 50070513, 50071151, 50100114, 50104791, 50104792, 50104793, 50826030, 53777279, 53788890, 53800550, 53800553, 56311741, 56463269, 57361610
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| ChEBI ID |
CHEBI:79090
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4307). | |||
| REF 2 | Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. | |||
| REF 3 | A selective inhibitor of p38 MAP kinase, SB202190, induced apoptotic cell death of a lipopolysaccharide-treated macrophage-like cell line, J774.1. Biochim Biophys Acta. 2000 Oct 18;1502(2):207-23. | |||
| REF 4 | Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res. 2003 Oct 1;59(4):893-900. | |||
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