Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F3CA
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| Former ID |
DNC007255
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| Drug Name |
3,4-dichloroisocoumarin
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| Synonyms |
3,4-dichloroisocoumarin; 51050-59-0; 3,4-Dcl; 3,4-Dichloro-1H-isochromen-1-one; 1H-2-Benzopyran-1-one,3,4-dichloro-; 3,4-DCI; 3,4 dichloroisocoumarin; 3,4-Dichloro-1H-2-benzopyran-1-one; 1H-2-Benzopyran-1-one, 3,4-dichloro-; CHEMBL24983; 3,4-dichloroisochromen-1-one; 3,4-Dichloro-2-benzopyran-1-one; C9H4Cl2O2; Lopac-D-7910; cid_1609; AC1Q3H9V; AC1L1BU9; Lopac0_000442; KBioGR_000269; KBioSS_000269; BSPBio_001549; MLS002153325; SCHEMBL106901; 3,4-Dichloro-isochromen-1-one; KBio3_000538; KBio2_002837; CTK4J3543; KBio2_005405
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C9H4Cl2O2
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl
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| InChI |
1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
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| InChIKey |
SUGXUUGGLDCZKB-UHFFFAOYSA-N
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| CAS Number |
CAS 51050-59-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:109540
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and G... Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. | |||
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