Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04NQI
|
|||
| Former ID |
DAP000699
|
|||
| Drug Name |
Amodiaquine
|
|||
| Synonyms |
Amodiachin; Amodiachinum; Amodiaquin; Amodiaquina; Amodiaquinum; Basoquin; CQA; Camochin; Camoquin; Camoquinal; Camoquine; Flavoquin; Flavoquine; Miaquin; Sunoquine; Amodiaquine hydrochloride; Amodiaquine USP24; SN 10751; AMODIAQUINE, FLAVOQUINE; Amodiaquina [INN-Spanish]; Amodiaquinum [INN-Latin]; CAM-AQ 1; CAM-AQI; Cam-AQ1; Camoquin (TN); Flavoquine (TN); SN 10,751; WR-002977; Amodiaquine (USAN/INN); Amodiaquine [USAN:INN:BAN]; Amodiaquine, ring-closed; S. N. 10751
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Therapeutic Class |
Antimalarials
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H22ClN3O
|
|||
| Canonical SMILES |
CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O
|
|||
| InChI |
1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
|
|||
| InChIKey |
OVCDSSHSILBFBN-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 86-42-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9828, 77901, 598064, 4621370, 7886759, 7978694, 8151472, 10537079, 10589213, 11466337, 11467457, 11486233, 15374079, 17397079, 29221344, 46393825, 46506940, 47291303, 47440457, 47589170, 47810953, 47959956, 48415557, 49698430, 49956414, 50085969, 53789783, 53801183, 57321182, 76179602, 81062056, 81093107, 84974934, 92712423, 103190631, 103973209, 104299796, 105086070, 124596739, 124659480, 124801466, 124951249, 125358735, 126630109, 126678259, 128866127, 131333557, 134337988, 134970939, 135702891
|
|||
| ChEBI ID |
CHEBI:2674
|
|||
| SuperDrug ATC ID |
P01BA06
|
|||
| SuperDrug CAS ID |
cas=000086420
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides uniformis
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Amodiaquin dihydrochloride dihydrate (adjusted p-values: 3.29E-03). | |||
|
Studied Microbe: Parabacteroides distasonis
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Amodiaquin dihydrochloride dihydrate (adjusted p-values: 8.09E-05). | |||
|
Studied Microbe: Parabacteroides merdae
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Amodiaquin dihydrochloride dihydrate (adjusted p-values: 2.40E-05). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine N-methyltransferase (HNMT) | Target Info | Inhibitor | [3] |
| BioCyc | Histamine degradation | |||
| KEGG Pathway | Histidine metabolism | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Histidine Metabolism | |||
| WikiPathways | Methylation Pathways | |||
| Metapathway biotransformation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Amodiaquine, 2008. eduDrugs. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.