Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03OLX
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| Former ID |
DNC009042
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| Drug Name |
5'-Deoxy-5'-(N,N-dimethylamino)adenosine
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| Synonyms |
5'-Deoxy-5'-(Dimethylamino)adenosine; 5'-Deoxy-5'-(N,N-dimethylamino)adenosine; SCHEMBL952928; CHEMBL472733; AdoMet substrate analogue, 23b; BDBM28453; SLNWRDWGFHZRAQ-WOUKDFQISA-N; ZINC40914070; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-[(dimethylamino)methyl]oxolane-3,4-diol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H18N6O3
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| Canonical SMILES |
CN(C)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
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| InChI |
1S/C12H18N6O3/c1-17(2)3-6-8(19)9(20)12(21-6)18-5-16-7-10(13)14-4-15-11(7)18/h4-6,8-9,12,19-20H,3H2,1-2H3,(H2,13,14,15)/t6-,8-,9-,12-/m1/s1
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| InChIKey |
SLNWRDWGFHZRAQ-WOUKDFQISA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Inhibitor | [1] |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. | |||
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