Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01SJT
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| Former ID |
DND000005
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| Drug Name |
PF-562271
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| Synonyms |
PF-00562271
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Pfizer
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H20F3N7O3S
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| Canonical SMILES |
CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
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| InChI |
1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30)
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| InChIKey |
MZDKLVOWGIOKTN-UHFFFAOYSA-N
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| CAS Number |
CAS 717907-75-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:91370
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00666926) Study Of PF-00562271, Including Patients With Pancreatic, Head And Neck, Prostatic Neoplasms. U.S. National Institutes of Health. | |||
| REF 2 | Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther. 2011 Nov;10(11):2135-45. | |||
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