Drug General Information
Drug ID D0O5NK
Drug Name Oseltamivir
Synonyms Tamiflu (*Phosphate salt 1:1*); Agucort; Oseltamivirum; Tamvir; GS 4104; GS4104; Agucort (TN); GS-4104; Oseltamivir (INN); Oseltamivir [INN:BAN]; Ro-640796; Tamiflu (TN); Tamiflu-Free; Ro-64-0796; OTV
Drug Type Small molecular drug
Therapeutic Class Antiviral Agents
Company Hoffmann-La Roche pharmaceutical company
Structure D0O5NK
Drug Resistance Mutations
Target Name Influenza Neuraminidase (NA) Target Info
Gene Name NA
Uniprot ID C3W5Y1_9INFA
Species Influenza A viruses H1N1
Reference Sequence MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCNQSVITYENNT
WVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREP
FISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWS
ASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFT
VMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN
RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIG
RTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRP
CFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK [Influenza
A viruses H1N1]
Targeted Disease Influenza infection
Drug Resistance Mutations
Mutation info Missense: E119G [1]
Mutation info Missense: H275Y [2]
Target Name Influenza Proton channel protein (M2) Target Info
Gene Name M2
Uniprot ID M2_I35A3
Species Influenza A viruses H1N1
Reference Sequence MSLLTEVETPIRNEWGCRCNGSSDPLVIAASIIGILHLILWILDRLLFKCIYRRFKYGLK
RGPSTEGVPESMREEYRKEQQSAVDADDGHFVNIEPE [Influenza A viruses H
1N1]
Targeted Disease Influenza infection
Drug Resistance Mutations
Mutation info Missense: S31N [2]
References
REF 1 Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Nov;100(2):356-64.
REF 2 Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76.

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