Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99189 | Target Info | |||
| Target Name | Sodium/bile acid cotransporter (SLC10A1) | ||||
| Synonyms |
Solute carrier family 10 member 1; Sodium/taurocholate cotransporting polypeptide; Na(+)/taurocholate transport protein; Na(+)/bile acid cotransporter; Cell growth-inhibiting gene 29 protein
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| Target Type | Successful Target | ||||
| Gene Name | SLC10A1 | ||||
| Biochemical Class | Bile acid:sodium symporter (BASS) (TC 2.A.28) family | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Ileal sodium/bile acid cotransporter (SLC10A2) | Successful Target | ||||
| UniProt ID | NTCP2_HUMAN | |||||
| Gene Name | SLC10A2 | |||||
| Synonyms |
Solute carrier family 10 member 2; Sodium/taurocholate cotransporting polypeptide, ileal; SLC10A2; Na(+)dependent ileal bile acid transporter; Ileal sodiumdependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; ISBT; IBAT; Apical sodiumdependent bile acid transporter; ASBT
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| Representative Drug(s) | LUM001 | Drug Info | IC50 = 890 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1183-6. | ||||
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