Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T98278 Target Info
Target Name HUMAN type-1 angiotensin II receptor (AGTR1)
Synonyms
Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; Angiotensin II receptor 1; Angiotensin 1 receptor; AT2R1B; AT2R1; AT1BR; AT1AR; AT1; AGTR1B; AGTR1A
    Click to Show/Hide
Gene Name AGTR1
Biochemical Class GPCR rhodopsin
UniProt ID
AGTR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Angiotensin II receptor type-2 (AGTR2) Successful Target
UniProt ID AGTR2_HUMAN
Gene Name AGTR2
Synonyms
Type-2 angiotensin II receptor; Angiotensin II type-2 receptor; Angiotensin II receptor 2; AT2
    Click to Show/Hide
Representative Drug(s) Telmisartan Drug Info IC50 = 0.33 nM [1]
Co-Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target
UniProt ID PPARG_HUMAN
Gene Name PPARG
Synonyms
PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
    Click to Show/Hide
Representative Drug(s) Telmisartan Drug Info EC50 = 700 nM [2]
Co-Target Name Liver organic anion transporter 2 (SLCO1B3) Literature-reported Target
UniProt ID SO1B3_HUMAN
Gene Name SLCO1B3
Synonyms
Solute carrier organic anion transporter family member 1B3; Solute carrier family 21 member 8; SLC21A8; Organic anion-transporting polypeptide 8; Organic anion transporter 8; OATP8; OATP1B3; OATP-8; Liver-specific organic anion transporter 2; LST2; LST-2
    Click to Show/Hide
Representative Drug(s) Telmisartan Drug Info Ki = 960 nM [3]
Co-Target Name Cytochrome P450 2J2 (CYP2J2) Co-Target
UniProt ID CP2J2_HUMAN
Gene Name CYP2J2
Synonyms
Albendazole monooxygenase (hydroxylating); Albendazole monooxygenase (sulfoxide-forming); Arachidonic acid epoxygenase; Hydroperoxy icosatetraenoate isomerase; CYPIIJ2
    Click to Show/Hide
Representative Drug(s) Telmisartan Drug Info Ki = 100 nM [4]
References  Top
REF 1 Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists. Eur J Med Chem. 2012 Mar;49:183-90.
REF 2 Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) gamma partial agonists. Eur J Med Chem. 2016 Nov 29;124:49-62.
REF 3 Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83(6):1257-67.
REF 4 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.