Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97136 | Target Info | |||
| Target Name | MAPK signal-integrating kinase 1 (MKNK1) | ||||
| Synonyms |
Mnk1; MAP kinase signal-integrating kinase 1
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| Target Type | Clinical trial Target | ||||
| Gene Name | MKNK1 | ||||
| Biochemical Class | Protein kinase superfamily. CAMK Ser/Thr protein kinase family | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | MAP kinase signal-integrating kinase 2 (MKNK2) | Clinical trial Target | ||||
| UniProt ID | MKNK2_HUMAN | |||||
| Gene Name | MKNK2 | |||||
| Synonyms |
Mnk2; MAPK signal-integrating kinase 2
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| Representative Drug(s) | EFT508 | Drug Info | IC50 = 1 nM | [1] | ||
| Co-Target Name | Cytoplasmic DRAK1 (STK17A) | Literature-reported Target | ||||
| UniProt ID | ST17A_HUMAN | |||||
| Gene Name | STK17A | |||||
| Synonyms |
Serine/threonine-protein kinase 17A; STK17A; DAP kinase-related apoptosis-inducing protein kinase 1
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| Representative Drug(s) | EFT508 | Drug Info | IC50 = 131 nM | [1] | ||
| Co-Target Name | CDC-like kinase 4 (CLK4) | Literature-reported Target | ||||
| UniProt ID | CLK4_HUMAN | |||||
| Gene Name | CLK4 | |||||
| Synonyms |
Dual specificity protein kinase CLK4
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| Representative Drug(s) | EFT508 | Drug Info | IC50 = 787 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J Med Chem. 2018 Apr 26;61(8):3516-40. | ||||
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